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LATEST NEWS<\/p>\n\n\n\n

Long-Distance Shipping of 3D Skin Models<\/h3>\n\n\n\n

Labskin has partnered with Atelerix to enable reliable, long-distance transport of our advanced in vitro skin models using Atelerix\u2019s non-cryogenic hydrogel technology. This innovation maintains the structural integrity and biological viability of our 3D skin constructs well beyond the traditional 72\u201396-hour window, allowing for global distribution without compromising quality.<\/p>\n\n\n\n

This breakthrough reduces the risks associated with customs delays and cold-chain logistics, helping us expand access to our full-thickness human skin models worldwide.<\/p>\n\n\n\n

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BBC Feature: Investigating Adult Acne<\/h3>\n\n\n\n

As one of the leading companies in the field of skin testing, Labskin Ltd was recently contacted by the BBC to assist them with a feature they wanted to do on adult acne.<\/p>\n\n\n\n

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LATEST PUBLICATIONS<\/p>\n\n\n\n

EFFECTs of anti-acne products on microbiota<\/h3>\n\n\n\n

Labskin Limited is proud to be featured in Personal Care<\/em> magazine with a case study exploring the effects of anti-acne products on the skin microbiome using Labskin-S<\/strong>. Led by Dr Nicola Kingswell, the study highlights how different products can reduce acne bacteria while balancing inflammation, providing valuable insights for microbiome-informed skincare development.<\/p>\n\n\n\n

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Using a full thickness bioengineered human skin equivalent as a model for radiation biology research<\/h3>\n\n\n\n

We\u2019re proud to see Labskin\u2019s human skin equivalent model applied in cutting-edge radiation biology research. A recent open-access article in Scientific Reports<\/em> describes how a bioengineered full-thickness skin equivalent, colonised with a natural mixed human microbiome, was used to examine molecular and microbial responses to x-ray exposure over extended time periods. The results demonstrate that the Labskin model remains viable, structurally stable, and functionally relevant\u2014even under radiation stress\u2014making it a powerful platform for biodosimetry, radiobiology, and therapeutic development.<\/p>\n\n\n\n

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LATEST RESEARCH ARTICLE<\/p>\n\n\n\n

SARS-CoV-2 survival on skin and its transfer from contaminated surfaces<\/h3>\n\n\n\n

The Liverpool School of Tropical Medicine, in collaboration with Unilever, recently published a study exploring how SARS-CoV-2 survives on skin and transfers from contaminated surfaces. We\u2019re proud to say they used the Labskin model to make it possible.<\/p>\n\n\n\n

This research highlights how Labskin can be applied to virology, infection control, and beyond \u2014 offering scientists a reproducible, ethical, and microbiome-ready alternative to human testing.<\/p>\n\n\n\n

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LATEST BLOG<\/p>\n\n\n\n

Top 10 Problems Skin Researchers Face<\/h3>\n\n\n\n

From ethical concerns to the complexities of replicating human skin conditions, researchers are constantly searching for innovative, reliable, and ethical solutions. Here we explore the top 10 challenges faced by skin researchers and how Labskin can provide the answers.<\/p>\n\n\n\n

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INTERVIEW<\/p>\n\n\n\n

Why Labskin-S Was the
Model of Choice for
SARS-CoV-2 Skin Studies<\/h3>\n\n\n\n

Discover the latest advances in viral transmission research with this in-depth report from Labskin. It explores innovative laboratory models and methods that are helping scientists better understand how viruses spread, offering valuable insights for drug development and public health.<\/p>\n\n\n\n

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LATEST POSTER<\/p>\n\n\n\n

Labskin full thickness with A375 melanoma cells as a medium to study Melanoma<\/h3>\n\n\n\n

This poster presents LabSkin\u2019s latest work using our 3D full-thickness skin equivalent<\/strong> as a platform to study melanoma progression. Built on a fibrin gel, LabSkin incorporates human dermal adult fibroblasts (HDFa)<\/strong> and human epidermal neonatal keratinocytes (HEKn)<\/strong> cultured through a staged process to recreate a physiologically relevant skin environment. To model melanoma, A375 spheroid clusters (up to 1 \u00d7 10\u2075 cells)<\/strong> are formed in Haem-coated plates and integrated into LabSkin prior to keratinocyte seeding. This approach enables researchers to investigate melanoma behaviour within a controlled, tissue-realistic system, supporting more predictive and ethical preclinical testing.<\/p>\n\n\n\n

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LATEST RESEARCH<\/p>\n\n\n\n

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AN INTRODUCTION TO THE SCALP MICROBIOME<\/strong><\/h2>\n\n\n\n

Analysis of the scalp microbiome and the microbiota that colonise this ecosystem is growing rapidly. <\/p>\n\n\n\n

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THE SCIENCE BEHIND SKIN MICROBIOME IN HEALTH AND DISEASE<\/strong><\/h2>\n\n\n\n

Discover why the skin microbiome is reshaping the skincare industry and how you can harness this knowledge to develop products that truly make a difference. <\/p>\n\n\n\n

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WHAT SHAMPOO INGREDIENTS REALLY DO TO YOUR SCALP MICROBIOME<\/strong><\/h2>\n\n\n\n

Discover how shampoo ingredients influence the scalp microbiome using Labskin\u2019s simplified 3D skin model, revealing more human-relevant insights into formulation impact and scalp health.<\/p>\n\n\n\n

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ACNE DEMOGRAPHICS AND MICROBIOME INSIGHTS<\/strong><\/strong><\/h2>\n\n\n\n

This whitepaper examines global acne trends and the role of the skin microbiome, revealing how microbiome-driven insights are transforming acne research and skincare innovation.<\/p>\n\n\n\n

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A FULL-THICKNESS 3D SKIN MODEL FOR ATOPIC DERMATITIS<\/strong><\/strong><\/h2>\n\n\n\n

LabSkin-AD is a physiologically relevant human in vitro model of atopic dermatitis that replicates key structural, inflammatory and microbiome features of the disease while enabling robust therapeutic testing and mechanistic insight.<\/p>\n\n\n\n

VIEW WHITEPAPER\u2192 <\/a> <\/strong> <\/p>\n\n\n\n

VIEW WEBINAR \u2192 <\/a> <\/strong> <\/p>\n<\/div>\n\n\n\n

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AN INTRODUCTION TO THE VAGINAL MICROBIOME<\/strong><\/h2>\n\n\n\n

Research into the vaginal microbiome and how it affects the overall health of women has accelerated over the last decade. <\/p>\n\n\n\n

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POSTERS<\/strong><\/h2>\n\n\n\n
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Colonisation of a 3D Skin Model<\/h2>\n\n\n\n

2018 L\u2019Occitane 3D Skin Model Complete Microbiota is more beneficial to skin barrier than Staphylococcus Epidermidis Alone<\/p>\n\n\n\n

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Drug Absorption in Living Skin<\/h2>\n\n\n\n

2017 Detection of drug absorption in living skin equivalent models by using MALDI-MSI<\/p>\n\n\n\n

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Non-invasive biodosimetry: space applications of skin swabs-based omics.<\/h2>\n\n\n\n

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2017 Proteomics and Substrate Based MS Imaging of Xenobiotic Metabolising Enzymes in ex Vivo Human Skin and a Human Living Skin Equivalent Model<\/h3>\n\n\n\n

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2015 MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model<\/h3>\n\n\n\n

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2013 In vitro screening of a human skin equivalent model<\/h3>\n\n\n\n

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LabSkin full thickness with A375 melanoma cells as<\/strong><\/h3>\n\n\n\n

a medium to study Melanoma<\/strong><\/p>\n\n\n\n

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Published Papers<\/mark><\/strong><\/h2>\n\n\n\n
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Challenges Developing a Human Model System for Skin Microbiome Research<\/strong> <\/p>\n\n\n\n

The human skin is colonised by a diversity of microorganisms. The human skin microbiome has come into great interest for its role in skin health and disease, and as a potential target for therapeutic and cosmetic applications (Byrd et al. 2018). A major limitation in the laboratory investigation of microbial and host-microbe interactions on human skin is the lack of a model that can reliably reproduce the complexity of the host. Attempts to model human microbial communities in rodents are impeded by competition from native flora, and even germ-free models suffer due to the substantial differences between murine and human integumentary systems.
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MDPI \u2013 2017 Non-Invasive Assessment of Skin Barrier Properties<\/strong> <\/p>\n\n\n\n

Investigating Emerging Tools for In Vitro and In Vivo Applications. <\/p>\n\n\n\n

There is increasing interest in the development of non-invasive tools for studying the properties of skin, due to the potential for non-destructive sampling, reduced ethical concerns and the potential comparability of results in vivo and in vitro. 
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L\u2019Occitane \u2013 Colonization of a 3D Skin Model<\/strong> <\/p>\n\n\n\n

3D skin models are getting closer to the reality of cutaneous physiology. They can include multiple cell types, from healthy or pathological skin or be submitted to various stresses mimicking the skin\u2019s environment. 
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International Journal of Cosmetic Science \u2013 2018 Examination of the Skin Barrier Repair Wound Healing Process<\/strong> 
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Damage to the structural integrity of the skin through trauma or injury initiates the skin barrier repair\/wound healing process, which is highly complex and carefully regulated with ordered responses. There are four main stages involved in the normal skin barrier repair\/wound healing process: haemostasis, inflammation, proliferation and remodelling, all of which occur in an over-lapping chronological sequence. 
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Journal of Antimicrobial Chemotherapy \u2013 Redox-active Compounds With A History Of Human Use<\/strong> <\/p>\n\n\n\n

To investigate the antistaphylococcal\/antibiofilm activity and mode of action (MOA) of a panel of redoxactive (RA) compounds with a history of human use and to provide a preliminary preclinical assessment of their potential for topical treatment of staphylococcal infections, including those involving a biofilm component. 
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Technology Review \u2013 Studying the Human Skin Microbiome Using 3D In Vitro Skin Models<\/strong> <\/p>\n\n\n\n

Three-dimensional(3D)human skin models are an accepted part of the testing and regulatory landscape in skin related industries and their development, commercialisation, and uses have been well documented. At present, there are several established commercial model systems and a multitude of academic lab-specific 3D in vitro reconstructed human skin models, all with different characteristics, strengths, and weaknesses. 
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Analytical Chemistry \u2013 Curcumin A Multipurpose Matrix for MALDI Mass Spectrometry Imaging Applications<\/strong> <\/p>\n\n\n\n

Turmeric (Curcuma longa) is a rhizomatous herbaceous plant belonging to the ginger family Zingiberaceae. The main components of tumeric are 1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione (also known as curcumin),which can exist in keto and enol forms (tautomers), and its desmethoxy and bis-desmethoxy derivatives which are present in varying ratios. 
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University of Leeds \u2013 Immune Responses of a Living Skin Equivalent Model Colonized by Staphylococcus Epidermidis or Staphylococcus Aureus<\/strong> <\/p>\n\n\n\n

Biofilms comprise structured communities of microorganisms in a self-produced extracellular matrix, usually attached to an organic or abiotic surface. 
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An aqueous watercress extract with topical anti-inflammatory properties in inflamed human skin<\/strong><\/p>\n\n\n\n

This new publication, co-authored by our Microbiology Services Manager Bart Cwkla<\/a><\/strong>, showcases how the Labskin<\/strong> model was used to demonstrate the anti-inflammatory potential of watercress extract. The study highlights Labskin\u2019s value in delivering reliable, human-relevant insights for skin research.<\/p>\n\n\n\n

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Protoemics Journal \u2013 2018 Mass Spectrometry Imaging of 3D Tissue Models<\/strong> <\/p>\n\n\n\n

A 3D cell culture is an artificially created environment in which cells are permitted to grow\/interact with their surroundings in all three dimensions. Derived from 3D cell culture, organoids are generally small-scale constructs of cells that are fabricated in the laboratory to serve as 3D representations of in vivo tissues and organs. 
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Elsevier Journal \u2013 Lipid Changes in Living Skin Equivalents in Response to Creams Containing Palmitoylethanolamide<\/strong> <\/p>\n\n\n\n

Whilst many immunohistochemistry, autoradiography and spectroscopic methods are routinely used in dermatological research, the application of MALDI MSI is still relatively new. One of the key features of MALDI MSI that makes its use appealing is the ability to detect and study the distribution of multiple compounds simultaneously in a label-free manner.  
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Journal of Antimicrobial Chemotherapy \u2013 2016 Tert-butyl Benzoquinone Mechanism of Biofilm Eradication<\/strong> <\/p>\n\n\n\n

Biofilms comprise structured communities of microorganisms in a self-produced extracellular matrix, usually attached to an organic or abiotic surface. <\/p>\n\n\n\n

For many bacteria, including a substantial proportion of those that cause human disease, the biofilm represents the usual mode of growth. Infections involving a substantial biofilm component (e.g. chronic wounds) are notoriously difficult to treat; not only does the physiological status of the bacteria inside the biofilm render them refractory to killing by extant anti bacterial drugs, but the extracellular matrix acts to physically shield the inhabitants from attack by the host\u2019s immune system. One approach to address the current difficulties we face in treating bio-film infections is to discover new antibacterial agents that demonstrate substantial killing and or eradication of bacterial biofilms. 
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Lipids In Health and Disease \u2013 Lipid Changes Within The Epidermis Of Living Skin Equivalents<\/strong> <\/p>\n\n\n\n

Mass spectrometry imaging (MSI) is a powerful tool for the study of intact tissue sections. Here, its application to the study of the distribution of lipids in sections of reconstructed living skin equivalents during their development and maturation is described. 
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Evocutis \u2013 3D Living Skin Models For Product Development<\/strong> <\/p>\n\n\n\n

Testing personal care products using clinical trials is the gold standard for proving efficacy, but is often seen as too expensive to be considered cost-effective. However, formal proof that a product works is highly motivating to consumers, as demonstrated by the runaway success of Boots Protect & Perfect anti-ageing serum in 2009. 
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University of Leeds \u2013 Microbial Colonization of an In Vitro Model of a Tissue-Engineered Human Skin Equivalent<\/strong> <\/p>\n\n\n\n

This was a preliminary investigation to define the conditions of colonization of a human skin equivalent (SE) model with cutaneous microorganisms. <\/p>\n\n\n\n

SEs of 24 mm diameter were constructed with a dermal matrix of fibrin containing fibroblasts and a stratified epidermis. Microbial colonisation of the SEs was carried out in a dry environment, comparable to \u2018in vivo\u2019 skin, using a blotting technique to remove inoculation fluid. The microbial communities were sampled by scrub washing and viable cells were enumerated on selective growth medium. 
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Effect of commonly used cosmetic preservatives on skin resident microflora dynamics<\/strong>

This study explores how everyday cosmetic preservatives influence the natural microbial communities living on human skin. Using Labskin\u2019s advanced 3D living skin model, researchers were able to track changes in the skin microbiome over time, providing valuable insights into how products interact with skin-resident microbes. The findings highlight the importance of considering microbial dynamics when formulating skincare products, ensuring they maintain a healthy skin ecosystem.
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Direct identification of bacterial and human proteins from infected wounds in living 3D skin models<\/strong>
In this research, Labskin\u2019s living 3D skin model was used to study protein interactions in infected wounds, enabling direct identification of both bacterial and human proteins. This approach provides a more realistic understanding of wound infections and the molecular responses of skin to microbial invasion. The study demonstrates the power of Labskin models for investigating complex skin biology and developing better strategies for wound care.

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APPLICATION NOTES<\/mark><\/strong><\/h2>\n\n\n\n
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AN001 Dandruff Malassezia 
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AN002 Anti-Ageing 
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AN003 Dermatophyte Invasion 
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AN004 IL-18 sensitisation assay 
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AN005 Tampons TSST-1 
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AN006 Percutaneous Absorption 
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AN007 Drug Penetration 
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AN008 Wounding & Healing 
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AN009 \u2018Omic\u2019 Analysis 
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AN010 Drug Metabolism 
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AN011 Immunohistochemistry of Labskin 
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AN012 Stratum Corneum Thickness 
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AN017 Wound dressings & Healing 
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AN018 Wounds & Biofilms 
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AN019 Inflammation 
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A comparison of the in vitro permeation of 3-O-ethyl-l-ascorbic acid in human skin and in a living skin equivalent (LabSkin<\/strong>).<\/a><\/p>\n\n\n\n

Iliopoulos F, Chapman A, Lane ME.Int J Cosmet Sci. 2021 Feb;43(1):107-112. doi: 10.1111\/ics.12675. Epub 2020 Dec 25.PMID: 33238056<\/p>\n\n\n\n

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Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model.<\/a><\/p>\n\n\n\n

Couto N, Newton JRA, Russo C, Karunakaran E, Achour B, Al-Majdoub ZM, Sidaway J, Rostami-Hodjegan A, Clench MR, Barber J.Drug Metab Dispos. 2021 Jan;49(1):39-52. doi: 10.1124\/dmd.120.000168. Epub 2020 Nov 2.PMID: 33139459<\/p>\n\n\n\n

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SARS-CoV-2 survival on skin and its transfer from contaminated surfaces.<\/a><\/p>\n\n\n\n

Pitol AK, Venkatesan S, Richards S, Hoptroff M, Majumdar A, Hughes GL.PLoS One. 2025 Jun 20;20(6):e0325235. doi: 10.1371\/journal.pone.0325235. eCollection 2025.PMID: 40540458 Free PMC article.<\/strong><\/p>\n\n\n\n

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MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model.<\/a><\/p>\n\n\n\n

Harvey A, Cole LM, Day R, Bartlett M, Warwick J, Bojar R, Smith D, Cross N, Clench MR.Proteomics. 2016 Jun;16(11-12):1718-25. doi: 10.1002\/pmic.201600036.PMID: 27226230 Free PMC article.<\/strong><\/p>\n\n\n\n

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Challenges in Developing a Human Model System for Skin Microbiome Research.<\/a><\/p>\n\n\n\n

Larson PJ, Chong D, Fleming E, Oh J.J Invest Dermatol. 2021 Jan;141(1):228-231.e4. doi: 10.1016\/j.jid.2020.05.096. Epub 2020 Jun 6.PMID: 32522484 Free PMC article.<\/strong> Review. No abstract available.<\/p>\n\n\n\n

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Development of dynamic cell and organotypic skin models, for the investigation of a novel visco-elastic burns treatment using molecular and cellular approaches.<\/a><\/p>\n\n\n\n

Wallace RG, Kenealy MR, Brady AJ, Twomey L, Duffy E, Degryse B, Caballero-Lima D, Moyna NM, Custaud MA, Meade-Murphy G, Morrin A, Murphy RP.Burns. 2020 Nov;46(7):1585-1602. doi: 10.1016\/j.burns.2020.04.036. Epub 2020 May 14.PMID: 32475797 Free article.<\/strong><\/p>\n\n\n\n

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Do Melanocytes Have a Role in Controlling Epidermal Bacterial Colonisation and the Skin Microbiome?<\/a><\/p>\n\n\n\n

Bi O, Caballero-Lima D, Sikkink S, Westgate G, Kauser S, Elies J, Thornton MJ.Exp Dermatol. 2025 Mar;34(3):e70071. doi: 10.1111\/exd.70071.PMID: 40051134 Free PMC article.<\/strong><\/p>\n\n\n\n

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LATEST NEWS Long-Distance Shipping of 3D Skin Models Labskin has partnered with Atelerix to enable reliable, long-distance transport of our advanced in vitro skin models using Atelerix\u2019s non-cryogenic hydrogel technology. This innovation maintains the structural integrity and biological viability of our 3D skin constructs well beyond the traditional 72\u201396-hour window, allowing for global distribution without … <\/p>\n

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